Some common pharmacological inhibitors of P-glycoprotein include: amiodarone, clarithromycin, ciclosporin, colchicine, diltiazem, erythromycin, felodipine, ketoconazole, lansoprazole, omeprazole and other proton-pump inhibitors, nifedipine, paroxetine, reserpine, saquinavir, sertraline, quinidine, tamoxifen, verapamil, ...
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Inhibitors of P-gp, Inducers of P-gp. Abrocitinib; Adagrasib; Amiodarone; Azithromycin (systemic); Belumosudil; Cannabidiol and cannabidiol-containing ...
Jul 20, 2021 · P-gp inhibitors are compounds that block or bypass P-gp efflux. The concurrent administration of P-gp inhibitors with P-gp substrates can ...
An antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic ...
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Inhibition of the function of P-gp is one strategy used to reverse MDR and sensitize tumor cells to conventional chemotherapeutics. Currently, despite ...
Aug 19, 2013 · Usually, an inhibitor of P-gp is coadministered with the drug to enhance drug absorption. Methods are being developed in preparing clinically ...
Elacridar is an orally active P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar can be used to examine the influence of ...
They inhibit P-gp efflux by acting on the lipid membrane and exhibit fewer side effects. Surfactants and polymers solubilize and stabilize the drug molecule.
Jun 5, 2023 · Drug Development and Drug Interactions | Table of Substrates, Inhibitors and Inducers ; P-gp. ABCB1. digoxin, fexofenadine(a,b,c,d), loperamide, ...