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FMRP phosphorylation modulates neuronal translation through YTHDF1
ScienceDirect.com
RNA-binding proteins (RBPs) control messenger RNA fate in neurons. Here, we report a mechanism that the stimuli-induced neuronal translation...
4 months ago
Genome-wide CRISPR screens identify noncanonical translation factor eIF2A as an enhancer of SARS-CoV-2 ...
ScienceDirect.com
Many positive-strand RNA viruses, including all known coronaviruses, employ programmed −1 ribosomal frameshifting (−1 PRF) to regulate the...
7 months ago
Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
Nature
Learning and memory require activity-induced changes in dendritic translation, but which mRNAs are involved and how they are regulated are...
3 weeks ago
The ribosome-associated protein RACK1 represses Kir4.1 translation in astrocytes and influences neuronal activity
ScienceDirect.com
The regulation of translation in astrocytes, the main glial cells in the brain, remains poorly characterized. We developed a high-throughput...
10 months ago
A dual-reporter system for investigating and optimizing protein translation and folding in E. coli
Nature
Strategies for investigating and optimizing the expression and folding of proteins for biotechnological and pharmaceutical purposes are in...
30 months ago
The protein translation machinery is expressed for maximal efficiency in Escherichia coli
Nature
Protein synthesis is the most expensive process in fast-growing bacteria. Experimentally observed growth rate dependencies of the...
42 months ago
Single-molecule imaging reveals translation-dependent destabilization of mRNAs
ScienceDirect.com
The relationship between mRNA translation and decay is incompletely understood, with conflicting reports suggesting that translation can...
14 months ago
NONU-1 Encodes a Conserved Endonuclease Required for mRNA Translation Surveillance
ScienceDirect.com
Cellular translation surveillance rescues ribosomes that stall on problematic mRNAs. During translation surveillance, endonucleolytic...
48 months ago
Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression
ScienceDirect.com
We uncover a tumor-suppressive process in urothelium called transcriptional-translational conflict caused by deregulation of the central...
11 months ago
Single-Molecule Imaging Reveals Translation of mRNAs Localized to Stress Granules
ScienceDirect.com
Cellular stress leads to reprogramming of mRNA translation and formation of stress granules (SGs), membraneless organelles consisting of...
40 months ago