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The ribosome-associated protein RACK1 represses Kir4.1 translation in astrocytes and influences neuronal activity
ScienceDirect.com
The regulation of translation in astrocytes, the main glial cells in the brain, remains poorly characterized. We developed a high-throughput proteomics...
11 months ago
Growth-rate dependency of ribosome abundance and translation elongation rate in Corynebacterium glutamicum ...
Nature
Bacterial growth rate (µ) depends on the protein synthesis capacity of the cell and thus on the number of active ribosomes and their translation elongation...
8 months ago
European Commission's Directorate-General for Translation Awards TRAD23
Slator
European Commission's Directorate-General for Translation names awardees of multi-million Euro TRAD23 contract.
1 month ago
Visualization of translation reorganization upon persistent ribosome collision stress in mammalian cells
ScienceDirect.com
Aberrantly slow ribosomes incur collisions, a sentinel of stress that triggers quality control, signaling, and translation attenuation.
3 months ago
Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
Nature
Learning and memory require activity-induced changes in dendritic translation, but which mRNAs are involved and how they are regulated are unclear.
1 month ago
Pseudouridine synthase 1 regulates erythropoiesis via transfer RNAs pseudouridylation and cytoplasmic translation
ScienceDirect.com
Pseudouridylation plays a regulatory role in various physiological and pathological processes. A prime example is the mitochondrial myopathy,...
2 months ago
Local γδ T cells: translating promise to practice in cancer immunotherapy | British Journal of Cancer
Nature
Rapid bench-to-bedside translation of basic immunology to cancer immunotherapy has revolutionised the clinical practice of oncology over the last decade.
11 months ago
FMRP phosphorylation modulates neuronal translation through YTHDF1
ScienceDirect.com
RNA-binding proteins (RBPs) control messenger RNA fate in neurons. Here, we report a mechanism that the stimuli-induced neuronal translation is mediated by...
5 months ago
Mechanistic dissection of premature translation termination induced by acidic residues-enriched nascent peptide
ScienceDirect.com
Ribosomes polymerize nascent peptides through repeated inter-subunit rearrangements between the classic and hybrid states.
4 months ago
Development of nanoRibo-seq enables study of regulated translation by cortical neuron subtypes, showing uORF ...
ScienceDirect.com
Investigation of translation in rare cell types or subcellular contexts is challenging due to large input requirements for standard approaches.
7 months ago