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MYCT1 alters the glycogen shunt by regulating selective translation of RACK1-mediated enzymes
ScienceDirect.com
MYCT1 has been shown to function as a tumor suppressor in various tumors, but its role in metabolism has never been reported.
26 months ago
Distinct pre-initiation steps in human mitochondrial translation
Nature
Translation initiation in human mitochondria relies upon specialized mitoribosomes and initiation factors, mtIF2 and mtIF3,...
47 months ago
Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome
ScienceDirect.com
Tactical disruption of protein synthesis is an attractive therapeutic strategy, with the first-in-class eIF4A-targeting compound zotatifin...
31 months ago
The source of the Black Death in fourteenth-century central Eurasia
Nature
The origin of the medieval Black Death pandemic (ad 1346–1353) has been a topic of continuous investigation because of the pandemic's...
23 months ago
Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer
ScienceDirect.com
Pancreatic ductal adenocarcinoma (PDAC) tumors have a nutrient-poor, desmoplastic, and highly innervated tumor microenvironment.
42 months ago
iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation
ScienceDirect.com
Post-translational modification of ribosomal proteins enables rapid and dynamic regulation of protein biogenesis.
32 months ago
Programmed −1 Ribosomal Frameshifting in coronaviruses: A therapeutic target
ScienceDirect.com
Human population growth, climate change, and globalization are accelerating the emergence of novel pathogenic viruses. In the past two decades alone,...
40 months ago
Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress
ScienceDirect.com
To survive, mammalian cells must adapt to environmental challenges. While the cellular response to mild stress has been widely studied,...
31 months ago
Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation ...
ScienceDirect.com
Transcriptional silencing of the FMR1 gene in fragile X syndrome (FXS) leads to the loss of the RNA-binding protein FMRP.
37 months ago
Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth
ScienceDirect.com
Glioblastoma stem cells (GSCs) resist current glioblastoma (GBM) therapies. GSCs rely highly on oxidative phosphorylation (OXPHOS),...
36 months ago